Table 2.

Serum multiplex tests of cachectic and noncachectic HNSCC patients

Cytokine (pg/mL)Cachectic (n = 10), (pg/mL)Noncachectic (n = 12), (pg/mL)P
IL-1α0 (0.0)0 (0.0)1.00
IL-1β3.6 (1.9)2.2 (2.3)0.15
IL-1a0 (0.0)0 (0.0)1.00
IL-21.9 (3.0)1.1 (2.1)0.53
IL-427.1 (7.1)24.2 (3.3)0.37
IL-50 (0.0)0 (0.0)1.00
IL-618.6 (16.2)9.6 (8.9)0.04
IL-8103.3 (21.6)98.1 (25.8)0.64
IL-100 (0.0)0.7 (2.5)0.36
IL-1729.4 (5.0)28.3 (1.3)0.52
TNF-α24.9 (2.2)25.6 (2.0)0.35
IFN-γ31.8 (13.1)33.2 (12.5)0.56
VEGF152.1 (37.7)145.6 (79.7)0.32
G-CSF57.5 (21.3)45.1 (10.7)0.11
GM-CSF31.9 (1.6)32.8 (3.6)0.84
MCP-1224.3 (92.3)216.9 (95.5)0.97
MIP-1α187.2 (17.9)175.0 (21.8)0.25
MIP-1β156.7 (38.3)149.0 (56.1)0.41
RANTES57,061 (54,626)79,887 (50,736)0.26
Tpo592.6 (93.6)641.5 (119.1)0.41
ENA-781,308.5 (853.5)3,536.3 (5,492.5)0.43
FGF37.3 (1.7)37.3 (1.6)0.67
  • NOTE: Values in table expressed as mean (SD).

  • Abbreviations: TNF-α, tumor necrosis factor-α; VEGF, vascular endothelial growth factor; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte/macrophage colony-stimulating factor; MCP-1, monocyte chemoattractant protein; MIP-1α and MIP-1β, macrophage inflammatory proteins 1α and 1β; RANTES, regulated on activation, normal T-cell expressed, and secreted; Tpo, thrombopoietin; ENA-78, epithelial-neutrophil activating peptide; FGF, fibroblast growth factor.