Table 2.

Telomere shortening and mitotic instability

CaseNo. TTAGGG-negative chromosome ends*MMsABs
10-10/20 (0%)0/54 (0%)
20-52/300 (0.6%)§5/35 (14%)§
30/300 (0%)§0/30 (0%)§
40-10/86 (0%)0/136 (0%)
50/15 (0%)0/39 (0%)
60/19 (0%)1/25 (3.8%)
70/300 (0%)§0/30 (0%)§
80-10/86 (0%)3/108 (2.7%)
90/103 (0%)2/115 (1.7%)
100-10/86 (0%)0/108 (0%)
11>101/72 (1.4%)12/32 (37.5%)
120-537/1129 (3.3%)52/697 (7.4%)
  • NOTE: Values above cutoff in bold type.

  • * The range of chromosome arms without signals for telomeric TTAGGG sequences.

  • Mitoses scored, percentage of MM in parenthesis.

  • Anaphase cells scored, percentage of AB in parenthesis.

  • § Scored in histopathology sections because the amount of tumor material available for culture was limited.

  • Not determined.

  • The exact number was not possible to estimate but the chromosome arms without telomeric signal were in no cell fewer than 10.