Table 3.

Grades of neutropenia and thrombocytopenia during DLT evaluation period according to dosage level and treatment stratum

Temozolomide dosage level (mg/m2)Number of patientsGrade of neutropenia
Grade of thrombocytopenia
01234DLT01234DLT
Stratum 1
2673300000300000
3553200100300000
4727201310330101 (0)
62810110085301600
8355 (4)00005 (4)2 (1)00113 (2)3 (2)*
Stratum 2
2673201000300000
3556113010411000
4726010053100500
  • NOTE: Numbers in parenthesis in stratum 1 reflect the results after exclusion of one DLT at the 472-mg/m2 dosage level that was not confirmed on central review and after the exclusion of one patient retrospectively declared ineligible at the 835 mg/m2 dosage level.

  • * Another patient required >2 platelet transfusions within 7 d, which was considered a dose-limiting toxicity.