Table 6.

Radiologic responses to therapy according to diagnosis and dosage level of temozolomide

Age at study entry/genderDiagnosisPrevious use of nitrosourea or temozolomideDosage level of temozolomide (mg/m2)Best radiologic responseNumber of courses completed
111.9/FMalignant gliomaYes267SD12
28.1/FMedulloblastomaYes355SD5
312.3/FPineoblastomaYes355SD11
412.5/FMedulloblastomaNo355SD5
516.9/MMalignant gliomaNo355PR4
616.2/MEpendymomaNo472SD6
712/FAnaplastic astrocytomaYes472SD11
84/FPilocytic astrocytomaNo472PR12
917.8/MGlioblastoma multiformeYes628SD5
102.1/FAnaplastic ependymomaNo628SD12
110.4/MAnaplastic ependymomaNo628PR12
  • Abbreviations: SD, stable disease; PR, partial response.