Table 1.

Correlations between tumor regression and pretreatment and posttreatment factors

Factor typeFactorCategoryRödel 0, n (%)Rödel 1, n (%)Rödel 2, n (%)P
PretreatmentClinicopathologicTherapyRadiotherapy53 (72)15 (20)6 (8)<0.001
Radiochemotherapy48 (38)64 (50)15 (12)
Clinical T stagecT338 (46)32 (38)13 (16)0.12
cT463 (53)47 (40)8 (7)
Differentiation gradeGood/moderate56 (58)31 (32)10 (10)0.03
Poor/undifferentiated20 (36)29 (52)7 (12)
Posttreatment*ypT stageypT1, T25 (29)12 (71)0.02
ypT3, T496 (59)66 (41)
ypN stageypN065 (50)49 (37)17 (13)0.38
ypN124 (51)19 (40)4 (9)
ypN212 (52)11 (48)0 (0)
ypTNMStage I5 (36)9 (64)0.16
Stage II51 (62)31 (38)
Stage III36 (55)30 (45)
CRMNegative71 (52)66 (48)0.03
Positive30 (70)13 (30)
HistologicTypeAdenocarcinoma75 (55)62 (45)0.50
Mucinous19 (53)17 (47)
Differentiation gradeGood/moderate62 (56)49 (44)0.40
Poor/undifferentiated39 (59)27 (41)
Growth patternCircumscript17 (68)8 (32)0.20
Diffuse83 (56)64 (44)
Lymphoid reactionNone/few56 (55)45 (45)0.20
Moderate32 (57)24 (43)
Extensive12 (80)3 (20)
Eosinophilic infiltrateNone71 (55)57 (44)0.19
Moderate/extensive29 (64)16 (36)
Lymphangio invasionNo94 (58)69 (42)0.54
Yes6 (54)5 (45)
CalcificationNo76 (60)50 (40)0.18
Yes25 (51)24 (49)
Tumor necrosisNo24 (32)52 (68)<0.001
Yes76 (78)22 (22)
  • Abbreviations: ypT, pathologic T stage; ypN, pathologic N stage; ypTNM, pathologic tumor stage.

  • * After a complete response (Rödel 2), posttreatment factors could not be assessed.