Table 3.

Multimarker methylation analysis in 71 RPFNA samples from 54 subjects: distribution of methylation markers versus Masood cytology index

Markers testedPercentage of hypermethylated samples for Masood score range (n)
≤10 (n = 12)11-12 (n = 21)13 (n = 21)14 (n = 8)≥15 (n = 9)
p1625% (3)8% (2)8% (2)13% (1)22% (2)
RARB M333% (4)62% (13)71% (15)63% (5)66% (6)
RARB M48% (1)19% (4)24% (5)25% (2)56% (5)
ESR133% (4)14% (3)15% (3)13% (1)44% (4)
BRCA125% (4)24% (5)0% (0)13% (1)22% (2)
  • NOTE: A total of 71 samples were tested for each methylation marker; n denotes the number of samples tested for each Masood cytology score range. For example, in Masood score of ≤10 (n = 12), 12 samples with a Masood cytology score were tested; of these 12 samples, three samples contained hypermethylation of the p16 promoter.