Table 4.

Multimarker methylation analysis in 71 RPFNA samples from 54 subjects: distribution of methylation markers versus age


Percentage of hypermethylated samples for age range (n)
≤40 y (n = 12)41-50 y (n = 25)51-64 y (n = 17)
p1633% (4)12% (3)18% (3)
RARB M383% (10)68% (17)71% (15)
RARB M425% (3)24% (6)35% (6)
ESR10% (0)7% (7)41% (7)
BRCA16% (1)20% (5)24% (4)
  • NOTE: A total of 54 samples were tested for each methylation marker; n denotes the number of samples tested for each age range. For example, for ages ≤40 y, 12 samples were tested; of these 12 samples, four samples contained hypermethylation of the p16 promoter.