Table 1.

Summary of drug-related adverse events (Common Terminology Criteria for Adverse Events grade ≥3) during the study

852A dose(mg/m2)
0.15 mg/m2 (n = 3)
0.3 mg/m2 (n = 3)
0.6 mg/m2 (n = 7)
1.2 mg/m2 (n = 6)
1.55 mg/m2 (n = 2)
2.0 mg/m2 (n = 4)
Total (N = 25)
CTCAE grade34343434343434
No. subjects with grade ≥3 drug-related adverse event10002031111284
Fever00001030002060
Fatigue00000001010204
Nausea00000000101020
Dehydration00000000101020
Vomiting00000000101020
Muscular weakness00000001100213
Myalgia00000010000010
Arthralgia00000010000010
Confusional state00000000100010
Deep vein thrombosis00001000000010
Injection site pain and irritation10000000000010
Neutrophil count decreased00001000000010
Peroneal nerve palsy00000010000010
  • Abbreviation: CTCAE, Common Terminology Criteria for Adverse Events.