Table 2.

Median Rmax values for type I IFN, IL-1RA, and IP-10

Dose (mg/m2)Rmax IFN-α (IU/mL)
Rmax IL-1RA (pg/mL)
Rmax IP-10 (pg/mL)
Dose 1Dose 6Dose 1Dose 6Dose 1Dose 6
0.150* (0-0)0 (0-0)0 (0-83)0 (0-95)0 (0-560)0 (0-0)
0.30 (0-0)0 (0-3)0 (0-36)39 (0-71)0 (0-0)43 (0-303)
0.69.2 (5-87)3.4 (0-16)10,300 (1,370-47,100)460 (0-887)4,500 (1,410-21,200)120 (0-1,570)
1.234 (6-1,250)81 (24-1,920)24,300 (5,350-59,700)4,660 (2,180-44,800)8,900 (4,390-67,900)3,200 (830-123,000)
1.556,500 (93-12,800)53,600 (47,600-59,700)79,400 (18,700-140,000)
2220 (150-673)710 (0-1,420)59,600 (59,100-59,800)30,800 (2,240-59,400)24,700 (15,500-120,000)7,100 (1,230-13,000)
  • NOTE: The values indicate median (range) serum cytokine Rmax for subjects by dose level and cytokine after dose 1 and dose 6 following 852A administration. Rmax is the maximum increase, by subject and dose, in measured serum cytokine compared with baseline controls.

  • * Median Rmax values indicated as zero depict values below the limit of quantitation or less than baseline levels.

  • Sample was not collected for cytokine determination.