Table 3.

Final estimates of docetaxel population pharmacokinetic variables in female Asian breast cancer patients based on model #20 in Table 2

VariableMedian population estimate (between subject variability)Bootstrap (95% CI)
Fixed effects
    V1 (L/h/70 kg/1.75 m)17.0 (20.9%)(15.0 to 19.0)
    Q (L/h/70 kg/1.75 m)11.7 (31.9%)(10.0 to 13.7)
    V2 (L/h/70 kg/1.75 m)173.0 (0.6%)(150.0 to 200.03)
    CL (L/h/70 kg/1.75 m)47.1 (22.5%)(39.1 to 58.4)
    MRT (h)4.04(3.27 to 5.0)
    A1AG−0.18(−0.24 to −0.08)
    FFAT0
    FHEP1−0.14(−0.31 to 0.01)
Covariate effects of SNPs
    CAR 180 C>T
        Wild type (n = 24)0
        Heterozygous (n = 39)−0.7(−0.88 to −0.32)
        Homozygous (n = 32)−0.44(−0.78 to 0.16)
    PXR −24381 A>C
        Wild type (n = 55)0
        Heterozygous (n = 31)0.13(−0.62 to 2.13)
        Homozygous (n = 9)−0.6(−0.91 to 0.79)
    HNF4α 49 A>G (Exon 1C)
        Wild type (n = 23)0
        Heterozygous (n = 40)−0.07(−0.56 to 1.07)
        Homozygous (n = 32)−0.024(−0.69 to 0.68)
    CAR-PXR interaction terms
        Wild type–wild type (n = 10)0
        Wild type–heterozygous (n = 10)-0.54(−0.8 to 0.15)
        Wild type–homozygous (n = 4)0.81(−0.44 to 4.03)
        Heterozygous–wild type (n = 24)1.81(0.4 to 4.1)
        Heterozygous-heterozygous (n = 12)0.46(−0.46 to 3.15)
        Heterozygous-homozygous (n = 3)5.77(1.04 to 16.7)
        Homozygous–wild type (n = 21)0.2(−0.41 to 1.56)
        Homozygous-heterozygous (n = 9)−0.33(−0.73 to 1.23)
        Homozygous-homozygous (n = 2)1.38(−0.07 to 5.51)
    HNF4α exon 1-PXR interaction terms
        Wild type–wild type (n = 18)0
        Wild type–heterozygous (n = 5)0.65(−0.33 to 2.72)
        Wild type–homozygous (n = 0)
        Heterozygous–wild type (n = 21)0.04(−0.53 to 1.33)
        Heterozygous-heterozygous (n = 14)0.74(−0.27 to 3.28)
        Heterozygous-homozygous (n = 5)0.29(−0.67 to 4.7)
        Homozygous–wild type (n = 16)0.27(−0.36 to 1.75)
        Homozygous-heterozygous (n = 12)0.98(−0.21 to 4.16)
        Homozygous-homozygous (n = 4)0.54(−0.56 to 4.64)
    HNF4α exon 1-CAR interaction terms
        Wild type–wild type (n = 5)0
        Wild type–heterozygous (n = 8)0.02(−0.57 to 1.55)
        Wild type–homozygous (n = 10)0.29(−0.45 to 2.09)
        Heterozygous–wild type (n = 11)0.004(−0.61 to 1.28)
        Heterozygous-heterozygous (n = 20)−0.01(−0.61 to 1.38)
        Heterozygous-homozygous (n = 9)0.39(−0.41 to 2.74)
        Homozygous–wild type (n = 8)−0.06(−0.58 to 1.16)
        Homozygous-heterozygous (n = 11)0.23(−0.53 to 2.35)
        Homozygous-homozygous (n = 13)0.54(−0.34 to 2.82)
    Residual error
        Proportional error (%)30.0
        Additive error (mg/L)0
  • Abbreviations: V1, volume of distribution in the central compartment; Q, intercompartmental clearance between central and peripheral compartments; V2, volume of distribution in peripheral compartment; FHEP1, liver function index when AST and/or ALT were above upper limits of normal.