Table 2.

Relationship between mRNA levels of TNC and various genes possibly involved in TNC deregulation in NF1

GenesGene definitionsNormal TNC-expressed MPNSTs (n = 3)TNC-overexpressed MPNSTs (n = 3)ROC-AUC
TNCTenascin C (hexabrachion)1.80 (1.49-2.28)*7.45 (7.15-9.70)1.000
AP-1 subunit genes
    JUNJun oncogene0.59 (0.34-0.81)2.13 (1.45-3.91)1.000
    JUNBJun B oncogene0.87 (0.11-1.30)1.51 (0.93-17.5)0.889
    JUNDJun D oncogene1.02 (0.98-1.13)4.01 (2.78-5.30)1.000
    FOSFos oncogene0.11 (0.05-1.21)0.54 (0.26-0.97)0.667
    FOSBFos B oncogene0.12 (0.04-1.06)0.40 (0.29-0.52)0.667
    ATF3Activating transcription factor 30.62 (0.35-1.59)2.57 (1.90-2.97)1.000
AP-1–induced genes
    MMP1Matrix metalloproteinase 11.60 (0.40-4.31)68.1 (11.9-182)1.000
    MAP3K8Mitogen-activated protein kinase kinase kinase 80.43 (0.14-0.77)1.99 (0.10-5.47)0.667
NF-κB subunit genes
    NFKB1Nuclear factor of κ light polypeptide gene (p105)0.72 (0.39-1.91)3.98 (1.00-6.29)0.889
    NFKB2Nuclear factor of κ light polypeptide gene (p49)1.01 (0.94-3.56)11.8 (2.18-16.6)0.889
    RELV-rel reticuloendotheliosis viral oncogene homologue1.03 (0.79-1.21)0.96 (0.55-5.27)0.444
    RELAV-rel reticuloendotheliosis viral oncogene homologue A0.44 (0.35-1.34)4.99 (1.21-6.14)0.889
    RELBV-rel reticuloendotheliosis viral oncogene homologue B0.36 (0.29-2.15)5.56 (2.37-31.2)1.000
NF-κB–induced genes
    BCL2ABCL2-related protein A10.34 (0.28-1.53)0.98 (0.96-1.41)0.667
    IER3SImmediate early response 3 (isoform short)1.10 (0.32-1.25)4.14 (2.36-9.98)1.000
    GADD45BGADD45 β1.29 (0.43-1.95)5.87 (1.32-14.9)0.889
    CD40LGCD40 ligand0.99 (0.05-1.31)1.74 (0.20-1.91)0.778
    PTGS2Prostaglandin-endoperoxide synthetase 2 (cyclooxygenase 2)1.03 (0.38-1.68)4.14 (0.57-6.86)0.778
    IL8Interleukin 81.40 (0.19-5.06)1.64 (0.91-191)0.667
    VEGFAVascular endothelial growth factor A3.05 (1.35-6.53)38.3 (5.5-69.0)0.889
    ICAM1Intercellular adhesion molecule 1 (CD54),1.16 (0.72-4.43)20.1 (3.52-27.2)0.889
    VCAM1Vascular cell adhesion molecule 11.47 (0.91-1.70)1.36 (0.65-3.91)0.444
    SELEE-selectin0.44 (0.24-0.74)0.38 (0.00-0.60)0.333
KROX24/EGR1 pathway
    EGR1Early growth response 1 (KROX-24)0.61 (0.27-1.39)1.25 (0.87-2.15)0.778
  • Abbreviation: ROC-AUC, receiver operating characteristics-area under the curve analysis.

  • * Median (range) of gene mRNA levels.