Table 2.

The potency of carboplatin in cells treated with the siRNA

siRNACarboplatin IC50 (μmol/L)
IGROV-1OVCAR-3OVCAR-4
NT49 ± 154.6 ± 0.330 ± 1
RISC-free55 ± 13
SCNN1A no. 152 ± 105.3 ± 0.627 ± 7
SCNNIA no. 257 ± 12
Bcl-XL no. 222 ± 8*3.1 ± 0.928 ± 3
Bcl-XL no. 430 ± 13*3.1 ± 1.423 ± 2
  • NOTE: IC50 values are expressed as mean ± SD, n = 3-4.

  • * P < 0.001, paired t test.

  • P < 0.05, paired t test.

  • P < 0.01, paired t test.