Table 3.

The potency of ABT-737 and carboplatin in primary cultures of ovarian cancer

PatientABT-737IC50 (μmol/L)
Combination index
CarboplatinCarboplatin and ABT-737
A26 ± 322 ± 311 ± 40.66 ± 0.12*
B19 ± 718 ± 715 ± 311 ± 0.3
C12 ± 613 ± 610 ± 411 ± 0.3
  • NOTE: The IC50 (mean ± SD, n = 3-6) of ABT-737, carboplatin or the combination of ABT-737 (1 μmol/L) and carboplatin was measured using a sulforhodamine B assay.

  • * P < 0.005, paired t test.