The potency of ABT-737 and carboplatin in primary cultures of ovarian cancer
| Patient | ABT-737 | IC50 (μmol/L) | Combination index | ||
|---|---|---|---|---|---|
| Carboplatin | Carboplatin and ABT-737 | ||||
| A | 26 ± 3 | 22 ± 3 | 11 ± 4 | 0.66 ± 0.12* | |
| B | 19 ± 7 | 18 ± 7 | 15 ± 3 | 11 ± 0.3 | |
| C | 12 ± 6 | 13 ± 6 | 10 ± 4 | 11 ± 0.3 | |
NOTE: The IC50 (mean ± SD, n = 3-6) of ABT-737, carboplatin or the combination of ABT-737 (1 μmol/L) and carboplatin was measured using a sulforhodamine B assay.
↵* P < 0.005, paired t test.