Table 1.

Dose escalation protocol for lonafarnib and paclitaxel

Dose levelLonafarnib dose (mg twice daily)Paclitaxel dose (mg/m2/wk)Patients (n)
1100607
2100807
31258010
4150803
  • NOTE: Lonafarnib was administered on days 3 to 28 in cycle 1 and on days 1 to 28 in all subsequent cycles. Paclitaxel was administered weekly during each cycle.