Table 3.

Summary of most frequent (>25%) treatment-emergent adverse events by dose level

Total
Lonafarnib dose (mg twice daily)100100125150
Paclitaxel dose (mg/m2/wk)60808080
No. patients7710327
Adverse event rate*Any severityGrade 3/4Any severityGrade 3/4Any severityGrade 3/4Any severityGrade 3/4Any severityGrade 3/4
    Diarrhea7 (100)2 (29)6 (86)07 (70)02 (67)022 (81)2 (7)
    Nausea5 (71)1 (14)6 (86)08 (80)1 (10)2 (67)021 (78)2 (7)
    Fatigue5 (71)04 (57)08 (80)2 (20)2 (67)1 (33)19 (70)3 (11)
    Vomiting5 (71)2 (29)2 (29)1 (14)8 (80)01 (33)016 (59)3 (11)
    Dyspnea5 (71)1 (14)3 (43)06 (60)1 (10)1 (33)015 (56)2 (7)
    Alopecia6 (86)03 (43)05 (50)00014 (52)0
    Anorexia4 (57)02 (29)05 (50)1 (10)2 (67)1 (33)13 (48)2 (7)
    Neuropathy2 (29)03 (43)1 (14)4 (40)01 (33)1 (33)10 (37)2 (7)
    Abdominal pain4 (57)01 (14)03 (30)0008 (30)0
    Coughing3 (43)01 (14)03 (30)01 (33)08 (30)0
    Epistaxis3 (43)01 (14)04 (40)0008 (30)0
    Dyspepsia2 (29)03 (43)03 (30)0008 (30)0
    Fever2 (29)01 (14)04 (40)01 (33)1 (33)8 (30)1 (4)
    Constipation1 (14)02 (29)05 (50)0008 (30)0
    Insomnia1 (14)03 (43)03 (30)01 (33)08 (30)0
    Rhinitis1 (14)02 (29)04 (40)01 (33)08 (30)0
    Taste perversion1 (14)02 (29)03 (30)01 (33)07 (26)0
    Arthralgia1 (14)02 (29)04 (40)0007 (26)0
  • * Values expressed as n (%).