Table 5.

Mean (CV) pharmacokinetic parameters of lonafarnib when administered in combination with paclitaxel

Dose*nCmax, ng/mLTmax, hAUC(0-12 h), ng·h/mLCL/F, mL/mintf, hPredose, ng/mL
100 + 606929 (77)4 (0-6)7,535 (93)382 (74)12 (0)434 (100)
100 + 804919 (61)4 (2-12)7,672 (71)307 (59)12 (0)494 (78)
125 + 8071,400 (30)4 (2-6)13,022 (32)172 (30)12 (0)726 (38)
150 + 8032,685 (NA)5 (4-6)19,729 (91)203 (65)12 (0)1,723 (110)
  • Abbreviation: NA, not appropriate (sample size = 2).

  • * Lonafarnib dose (mg) twice daily + paclitaxel dose (mg/m2) weekly.

  • Median value (range).