Table 2.

Summary of clinical toxicities for all cycles of therapy

No. cycles with toxicity grade 2/3/4 at dose level
12345678
No. patients evaluated33333666
No. cycles delivered1067811191213
Hematologic
    Anemia0/1/01/0/01/0/00/1/0
    Leukopenia2/1/00/2/0*0/2/0
    Neutropenia0/3/20/1/00/1/3
    Febrile neutropenia0/0/10/1/0
Nonhematologic
    Fatigue1/0/03/0/01/0/01/0/01/0/03/0/02/0/0
    Hypersensitivity1/0/00/1/0
    Mucositis1/0/01/1/0
    Myalgia/arthralgia4/0/01/0/01/1/02/0/0
    Nausea/vomiting0/1/01/0/0
    Neuropathy1/0/03/1/01/0/0
    Transaminitis0/1/01/0/0
  • NOTE: Entries were not made for dose levels where the indicated toxicity was not observed.

  • * Includes lymphopenia in one cycle.