Table 2.

Pharmacokinetic variables of pegvisomant after daily s.c. pegvisomant administration to healthy subjects for 14 days

Dose (mg/d)nVariables (mean ± SD)
Ctrough,day14 (μg/mL)AUC0-day14 (μg·h/mL)AUC0-inf (μg·h/mL)t1/2 (h)
401777.3 ± 21.215,668 ± 4,286NC*NC*
601887.8 ± 19.514,544 ± 2,78143,866 ± 7,95764.7 ± 10.9
8016129 ± 29.721,337 ± 3,76365,651 ± 10,12893.8 ± 74.9
  • Abbreviation: NC, not calculated.

  • * Blood samples for pharmacokinetics were not collected after the last dose.