Table 3.

Univariate and multivariate analyses of prognosis factors associated with overall and disease-free survival in patients with HCC

VariablesUnivariate analysis
Multivariate analysis

Hazard ratio (95% confidence interval)
P
Hazard ratio (95% confidence interval)
P
(A) Univariate and multivariate analyses of prognosis factors associated with overall survival in patients with HCC
Prevalence of tumor-infiltrating FOXP3+ Tregs among CD4+ T cells in HCC (high/low)1.791 (1.163-2.760)0.0081.640 (1.023-2.628)0.040
Prevalence of tumor-infiltrating CD8+ Tcells in total T cells in HCC (high/low)1.055 (0.687-1.620)0.8061.109 (0.681-1.805)0.678
Age* (≥63 y/<63 y)1.003 (0.653-1.540)0.9890.909 (0.573-1.440)0.684
Gender (male/female)1.052 (0.636-1.740)0.8440.957 (0.554-1.655)0.876
Viral hepatitis (presence/absence)1.140 (0.496-2.620)0.7570.972 (0.332-2.842)0.958
Nontumor liver (NCH/CH, PC, LC)0.766 (0.369-1.592)0.4750.503 (0.207-1.225)0.130
Child-Pugh score (A/B, C)0.462 (0.222-0.962)0.0390.395 (0.171-0.913)0.030
TNM stage (I, II/III, IV)0.412 (0.256-0.663)<0.0011.079 (0.456-2.548)0.863
Tumor size* (≥37 mm/<37 mm)1.398 (0.909-2.149)0.1271.018 (0.553-1.875)0.954
AFP* (≥27.1 ng/mL/<27.1 ng/mL)1.673 (1.084-2.581)0.0201.454 (0.901-2.347)0.125
Histologic grade (WD HCC/MD HCC, PD HCC)0.637 (0.376-1.078)0.0930.931 (0.489-1.772)0.828
VP (presence/absence)2.843 (1.825-4.429)<0.0012.546 (1.323-4.900)0.005
IM (presence/absence)2.880 (1.786-4.641)<0.0012.081 (0.916-4.730)0.080
Prevalence CD8+ T cells in total T cells in nontumor liver (high/low)0.754 (0.490-1.159)0.1980.688 (0.419-1.131)0.140
Prevalence of FOXP3+ Tregs among CD4+ T cells in nontumor liver (high/low)0.756 (0.491-1.165)0.2050.737 (0.442-1.229)0.241
(B) Univariate and multivariate analyses of prognosis factors associated with disease-free survival in patients with HCC
Prevalence of tumor-infiltrating FOXP3+ Tregs among CD4+ T cells in HCC (high/low)1.701 (1.105-2.619)0.0161.706 (1.073-2.713)0.024
Prevalence of tumor-infiltrating CD8+ T cells in total T cells in HCC (high/low)1.150 (0.750-1.765)0.5221.330 (0.817-2.165)0.251
Age* (≥63 y/<63 y)0.917 (0.597-1.407)0.6910.803 (0.508-1.271)0.350
Gender (male/female)0.992 (0.600-1.641)0.9760.941 (0.546-1.619)0.825
Viral hepatitis (presence/absence)0.931 (0.405-2.140)0.8660.754 (0.249-2.287)0.619
Nontumor liver (NCH/CH, PC, LC)0.902 (0.435-1.871)0.7820.537 (0.215-1.342)0.184
Child-Pugh score (A/B, C)0.458 (0.220-0.955)0.0370.463 (0.206-1.039)0.062
TNM stage (I, II/III, IV)0.357 (0.220-0.577)<0.0010.808 (0.320-2.038)0.651
Tumor size* (≥37 mm/<37 mm)1.455 (0.947-2.235)0.0871.171 (0.635-2.159)0.614
AFP* (≥27.1 ng/mL/<27.1 ng/mL)1.556 (1.010-2.397)0.0451.503 (0.932-2.421)0.944
Histologic grade (WD HCC/MD HCC, PD HCC)0.810 (0.481-1.365)0.4291.354 (0.722-2.538)0.345
VP (presence/absence)2.284 (1.476-3.535)<0.0011.692 (0.870-3.294)0.121
IM (presence/absence)3.512 (2.163-5.704)<0.0012.487 (1.020-6.064)0.045
Prevalence CD8+ T cells in total T cells in nontumor liver (high/low)0.727 (0.473-1.118)0.1460.644 (0.393-1.054)0.080
Prevalence of FOXP3+ Tregs among CD4+ T cells in nontumor liver (high/low)0.800 (0.520-1.230)0.3090.788 (0.482-1.290)0.344
  • Abbreviations: MD, moderately differentiated; PD, poorly differentiated; WD, well differentiated.

  • * Two groups were divided by the median.