Table 1.

Dimethoxycurcumin metabolites

Dimethoxycurcumin metabolite (m/z)Proposed transformationQ1*MRM/EPIPrec/EPI
397Parent compound+++
369−28/2×(O-demethylation)++
371§−26/2×(O-demethylation)+H2++
383−14/(O-demethylation)+++
385−12/(O-demethylation)+H2++
399+2/+H2+++
401+4/+2H2++
559+162/(O-demethylation)+Glu++
561+164/(O-demethylation)+H2+Glu+
  • * Detection by Q1 scan (m/z 90-800).

  • Detection by MRM (based on transitions 397→191, 397→313, and known biotransformation reactions).

  • Precursor ion scan (of m/z 191).

  • § Observed in mouse microsome incubates only.