Table 2.

Dose-limiting toxicities during the first course of each dose level

Dose level (mg/m2)Number enrolledNumber evaluableNumber of patients with dose-limiting toxicities during cycle 1Dose-limiting toxicities (no. of patients)
1.3630
1.7622Confusion/CN XII palsy (n = 1), Grade 4 hypotension, grade 4 febrile neutropenia and grade 3 creatinine (n = 1)