Table 3.

Pharmacokinetic variables from noncompartmental analysis (Cmax and AUC) and a three-compartment model analysis (t1/2α, t1/2β and t1/2γ, Vc and Cl) of bortezomib in plasma

Dose (mg/m2)Cmax (ng/mL)AUCinf (h ng/mL)t1/2α (min)t1/2β (min)t1/2γ (min)Vc (L/m2)Cl (mL/h/m2)
1.344303.5326001341
1.373281.4348162.131
1.370233.0417585.642
Mean63272.7367256.738
SD163.00.94.1914.54.8
1.754426.0457191637
1.741*476.6791,5341322
  • Abbreviations: Cmax, maximum serum concentration at 5 min; AUCinf, area under the concentration-time curve extrapolated to infinity; t1/2α, distribution half-life; t1/2γ, elimination half-life; Vc, volume of distribution in the central compartment; Cl, clearance.

  • * Cmax determined at 13 min.