Table 3.

Drug levels in brain metastases and neighboring tissues, measured at time of resection or at autopsy

DrugTumor level: necrotic lesionTumor level: viable lesionNeighboring normal brain level
Etoposide (63)5.9 μg/g3.4 μg/g1.4 μg/g adjacent, 0.1 μg/g 2 cm distance
Cisplatin (64)
    20 to 25 mg/m2Not reported1.29 μg/g0.25 to 0.65 μg/g, 2 to 5 cm
    60 to 100 mg/m22.97 μg/g0.7 to 1.11 μg/g, 2 to 5 cm
Vinorelbine (65)Not reported68 ng/g22 ng/g adjacent, 5 ng/g >4 cm
Mitoxantrone (66)15 to 322 ng/g25 to 29 ng/gNot reported