Table 1.

Dose fractionation schemes in randomized trials of WBRT alone for brain metastases

StudyYearNo. patientsRandomization (Gy/no. fractions)Median survival (mo)
Harwood and Simpson (87)197710130/10 vs 10/14.0-4.3
Kurtz et al. (88)198125530/10 vs 50/203.9-4.2
Borgelt et al. (89, 90)198013810/1 vs 30/10 vs 40/204.2-4.8
Borgelt et al. (89, 90)19816412/2 vs 20/52.8-3.0
Chatani et al. (91)19867030/10 vs 50/203.0-4.0
Haie-Meder et al. (92)199321618/3 vs 36/6 or 43/134.2-5.3
Chatani et al. (93)19947230/10 vs 50/20 or 20/52.4-4.3
Murray et al. (94)199744554.4/34 vs 30/104.5