Table 1.

Activity of ARRY-142886 (10 μmol/L) against other kinases

KinasePercentage of control
p38α88
MKK6100
EGFR90
ErbB2100
ERK2100
B-Raf100
CDK2/cyclinA93
c-Raf98
c-Src95
Insulin receptor kinase103
JNK2α2100
MAPKAP-K2101
PDGFRα99
PKBα97
PKCα93
  • Abbreviations: PDGFR, platelet-derived growth factor receptor; CDK, cyclin-dependent kinase; JNK, c-Jun NH2-terminal kinase; PKBα, protein kinase Bα; PKCα, protein kinase Cα.