Table 2.

Inhibition of cell growth in human cell lines

NameTypeRas/Raf mutation (reported)IC50 (nmol/L) ± SE
HT-29ColonB-Raf175 ± 42
Malme-3MMelanomaB-Raf59 ± 4
MIA PaCa-2PancreaticK-Ras473 ± 169
SK-MEL-2MelanomaN-Ras200 ± 35
SK-MEL-28MelanomaB-Raf93 ± 17
BxPC3PancreaticNone reported>8,000
BT474BreastWT>50,000
Zr-75-1BreastWT>50,000
Malme-3Normal fibroblastNone reported>50,000