Table 4.

Summary of pharmacokinetic parameters of 17-AAG and 17-AG

Dose (mg/m2)n17-AAG Cmax (μmol/L)17-AAG AUC (μmol/L × h)17-AAG t1/2 (h)17-AAG clearance (L/h/m2)
Mean (SD)
11234.96 (0.99)8.33 (5.22)1.57 (0.32)31.57 (21.99)
150-15776.05 (1.95)13.81 (3.88)2.11 (0.57)20.16 (4.75)
210-22097.52 (3.25)21.69 (10.24)3.78 (2.15)21.19 (10.38)
307314.90 (3.75)38.77 (5.46)2.80 (0.92)13.73 (2.03)
Dose (mg/m2)n17-AG Cmax (μmol/L)17-AG Tmax (h)17-AG AUC (μmol/L × h)17-AG t1/2 (h)
Mean (SD)
11231.6 (0.4)1.0 (0.9)5.4 (2.7)5.0 (3.8)
150-15772.3 (1.1)1.4 (0.5)15.1 (8.7)7.5 (5.7)
210-22093.0 (1.2)1.7 (0.5)21.0 (13.0)6.9 (4.3)
30732.8 (1.4)1.7 (0.6)21.0 (13.2)9.7 (11.1)
  • Abbreviations: Cmax, maximum plasma concentration; AUC, area under the curve, t1/2, elimination half-life; Tmax, time to maximum plasma concentration.