Table 4.

Pharmacokinetics of 17-AAG and 17-AG

Dose (mg/m2)17-AAG17-AG
t1/2 (h)Cmax (ng/mL)AUC0-8 (ng/mL h)Cl (L/h/m2)AUC0-8 (ng2/mL h)MRT (h)Vss(L/m2)t1/2 (h)Cmax (ng/mL)AUC0-8 (ng/mL h)
1503.15 ± 0.402,189 ± 3825,022 ± 1,18930.5 ± 6.315,424 ± 7,9372.46 ± 0.8572.1 ± 16.06.1 ± 0.7958 ± 2254,014 ± 1,929
2703.24 ± 0.805,303 ± 1,59113,656 ± 4,75721.78 ± 7.5937,089 ± 13,3752.21 ± 0.2543.2 ± 12.14.6 ± 1.52,139 ± 1,10510,213 ± 4,983
  • NOTE: All values are expressed as mean + SD.

    Abbreviations: Cl, clearance; MRT, mean residence time.