Table 2.

Patient cohorts and DLTs

Dose levelSchedule17-AAG dose (mg/m2)Cycle duration (d)PatientsDLTsDescription of DLTs
1Daily × 552110
2Daily × 5102110
3Daily × 5202120
4Daily × 5402130
5Daily × 5802172Thrombocytopenia (1 pt), diarrhea/hepatitis (1 pt)
6Daily × 5562130
7Daily × 3801430
8Daily × 31121481Emesis (1 pt)
9Daily × 31571442Nausea (1 pt), dyspnea (1 pt)
10Days 1, 4, 8, and 111122130
11Days 1, 4, 8, and 111572140
12Days 1, 4, 8, and 112202161Hepatitis (1 pt)
13Days 1, 4, 8, and 113072132Seizure (1 pt), abdominal pain/nausea/fever (1 pt)
14Days 1 and 41502130
15Days 1 and 42102130