Table 3.

Adverse events (all cycles)

Daily × 5Daily × 3
Grade 1Grade 2Grade 3Grade 4Grade 1Grade 2Grade 3Grade 4
No. patients1715
No. courses5055
Adverse events
    Nausea9 (53%)1 (6%)6 (40%)1 (7%)1 (7%)
    Emesis5 (29%)1 (6%)2 (13%)1 (7%)1 (7%)
    Diarrhea3 (18%)1 (6%)1 (6%)5 (33%)3 (20%)
    AST6 (35%)2 (12%)1 (6%)1 (6%)6 (40%)4 (27%)
    ALT5 (29%)1 (6%)1 (6%)1 (6%)6 (40%)2 (13%)1 (7%)*
    Platelets3 (18%)1 (6%)4 (27%)1 (7%)
Days 1, 4, 8, and 11Days 1 and 4 weekly
Grade 1Grade 2Grade 3Grade 4Grade 1Grade 2Grade 3Grade 4
No. patients166
No. courses5633
Adverse events
    Nausea6 (38%)4 (25%)1 (17%)2 (33%)
    Emesis4 (25%)2 (13%)1 (17%)
    Diarrhea5 (31%)3 (19%)1 (6%)3 (50%)1 (17%)
    AST4 (25%)4 (25%)1 (17%)1 (17%)2 (33%)1 (17%)
    ALT4 (25%)1 (6%)1 (17%)4 (67%)
    Platelets2 (13%)1 (17%)
  • * Abnormal lab value in this patient likely attributable to antibiotic therapy.