Table 1.

Effect of nab-paclitaxel on radioresponse of OCa-I tumors measured by tumor growth delay: timing of administration

Treatment*Tumor growth delayEnhancement factors
Time in days required to grow from 7 to 12 mmAbsolute growth delayNormalized growth delay§
Control (no treatment)15.8 ± 1.0
Nab-paclitaxel only36.7 ± 3.520.9 ± 3.5
Single-dose radiation only (10 Gy)29.4 ± 2.113.6 ± 2.1
Nab-paclitaxel + 10 Gy, 9 h later54.5 ± 2.738.7 ± 2.717.8 ± 2.71.3
Nab-paclitaxel + 10 Gy, 1 d later56.3 ± 3.940.5 ± 3.919.6 ± 3.91.4
Nab-paclitaxel + 10 Gy, 2 d later69.6 ± 2.653.8 ± 2.632.9 ± 2.62.4
Nab-paclitaxel + 10 Gy, 3 d later68.9 ± 3.053.1 ± 3.032.2 ± 3.02.4
Nab-paclitaxel + 10 Gy, 4 d later63.1 ± 3.047.3 ± 3.026.4 ± 3.01.9
Nab-paclitaxel + 10 Gy, 5 d later58.4 ± 3.642.6 ± 3.621.7 ± 3.61.6
Radiation 10 Gy + nab-paclitaxel, 1 d later41.8 ± 5.026.0 ± 5.05.1 ± 5.00.4
  • * Groups of 8 to 9 mice bearing 7-mm tumors in the right hind leg were given a single dose of nab-paclitaxel (90 mg/kg i.v.), a single dose of local tumor irradiation, or a combination of both agents at varying time intervals.

  • Enhancement factors obtained by dividing normalized growth delay in mice treated with nab-paclitaxel plus radiation by absolute tumor growth delay in mice treated with radiation alone.

  • Absolute tumor growth delay caused by nab-paclitaxel, radiation, or the combination of agents is defined as the time in days tumors required to grow from 7 mm to 12 mm minus the time in days untreated tumors required to grow from 7 mm to 12 mm.

  • § Normalized tumor growth delay is defined as the time in days for tumors to reach 12 mm in mice treated with the combination of nab-paclitaxel and radiation minus the time in days to reach 12 mm in mice treated with drug alone.