Table 1.

The homology of target site (within RRM2 mRNA) of the siR2B+5 duplex was explored across various species

SpeciesGenbank accession numberTarget site locationTarget sequenceHomology (to human)
HumanNM_001034nt 637-6555′ gauuuagccaagaaguuca 3′19/19 (100%)
MouseNM_009104nt 500-5185′ gauuuagccaagaaguuca 3′19/19 (100%)
RatNM_001025740nt 497-5155′ gauuuagccaagaaguuca 3′19/19 (100%)
DogXM_540076nt 488-5065′ gguuuagccaagaaguuca 3′18/19 (94.7%)
Monkey*nt 40285-403035′ gauuuagccaagaaguuca 3′19/19 (100%)
  • NOTE: The mismatched base in the canine sequence is identified by an underline.

  • * Sequence alignment was done between hRRM2 mRNA and a Rhesus sequence scaffold (10568:34896-42414) at http://genome.ucsc.edu/.