Mean (SD) pharmacokinetic parameters following the first CNTO 95 i.v. infusion
| Dose | Cmax (μg/mL) | AUC (μg·day/mL) | t1/2 (day) | CL (mL/day/kg) | Vz (mL/kg) |
|---|---|---|---|---|---|
| 0.1 mg/kg, N | 6 | 4 | 4 | 4 | 4 |
| Mean (SD) | 0.65 (0.15) | 0.32 (0.09) | 0.26 (0.02) | 326.19 (85.81) | 122.67 (25.58) |
| 0.3 mg/kg, N | 3 | 3 | 3 | 3 | 3 |
| Mean (SD) | 4.76 (0.38) | 4.66 (0.47) | 0.62 (0.02) | 64.90 (7.00) | 58.57(7.75) |
| 1 mg/kg, N | 3 | 2 | 2 | 2 | 2 |
| Mean (SD) | 17.80 (1.72) | 42.77 (2.23) | 1.08 (0.08) | 23.41 (1.22) | 36.75 (0.94) |
| 3 mg/kg, N | 3 | 3 | 3 | 3 | 3 |
| Mean (SD) | 58.54 (8.67) | 196.52 (62.11) | 1.51 (0.23) | 16.28 (4.91) | 34.92 (9.89) |
| 10 mg/kg, N | 8 | 8 | 8 | 8 | 8 |
| Mean (SD) | 225.95 (21.91) | 1,504.27 (171.09) | 6.70 (2.42) | 6.74 (0.83) | 63.33 (17.65) |
NOTE: Cmax, maximum observed CNTO 95 concentration; AUC, area under the concentration-time curve for CNTO 95; t1/2, half-life; CL, clearance; Vz, volume of distribution.