Table 3.

Mean (SD) pharmacokinetic parameters following the first CNTO 95 i.v. infusion

DoseCmax (μg/mL)AUC (μg·day/mL)t1/2 (day)CL (mL/day/kg)Vz (mL/kg)
0.1 mg/kg, N64444
    Mean (SD)0.65 (0.15)0.32 (0.09)0.26 (0.02)326.19 (85.81)122.67 (25.58)
0.3 mg/kg, N33333
    Mean (SD)4.76 (0.38)4.66 (0.47)0.62 (0.02)64.90 (7.00)58.57(7.75)
1 mg/kg, N32222
    Mean (SD)17.80 (1.72)42.77 (2.23)1.08 (0.08)23.41 (1.22)36.75 (0.94)
3 mg/kg, N33333
    Mean (SD)58.54 (8.67)196.52 (62.11)1.51 (0.23)16.28 (4.91)34.92 (9.89)
10 mg/kg, N88888
    Mean (SD)225.95 (21.91)1,504.27 (171.09)6.70 (2.42)6.74 (0.83)63.33 (17.65)
  • NOTE: Cmax, maximum observed CNTO 95 concentration; AUC, area under the concentration-time curve for CNTO 95; t1/2, half-life; CL, clearance; Vz, volume of distribution.