Table 1.

Effect of treatments on histologic distribution of lesions in TRAMP mice at 24 wks

Treatment groupnHistology
PLN Mets (%)P
NormalPINWDMDPD
Castration + 5-aza19585003721
PBS2101414567<0.0001*430.19
5-Aza22144150410.007180.10§
Castration1930000700.19370.29
  • Abbreviations: PIN, prostatic intraepithelial neoplasia; WD, well-differentiated prostate cancer; MD, moderately differentiated prostate cancer; PD, poorly-differentiated prostate cancer; LN, lymph node; Mets, metastasis.

  • * Fisher's exact test comparing the frequency of normal pathology between castration + 5-aza and PBS groups.

  • Fisher's exact test comparing the frequency of lymph node metastasis between castration + 5-aza and PBS groups.

  • Fisher's exact test comparing the frequency of normal pathology between castration + 5-aza and 5-aza groups.

  • § Fisher's exact test comparing the frequency of lymph node metastasis between 5-aza and PBS groups.

  • Fisher's exact test comparing the frequency of normal pathology between castration + 5-aza and castration groups.

  • Fisher's exact test comparing the frequency of lymph node metastasis between castration and 5-aza groups.