Table 4.

Patients with post-baseline changes in hematology and chemistry laboratory tests (N = 74)

Laboratory testPatients with a change in the post-baseline test, n (%)*ImprovedWorsenedClinically meaningful change, n (%)
Hematology
    Platelet count31 (42)0316 (8)
    Hemoglobin27 (36)0275 (7)
    WBC count21 (28)4176 (8)
    Neutrophil count10 (14)198 (11)
Chemistry
    Hyperglycemia40 (54)04018 (24)
    Hypertriglyceridemia34 (46)2322 (3)
    Creatinine increased30 (41)0303 (4)
    Proteinuria30 (41)1293 (4)
    Total CO223 (31)0235 (7)
    Hypercholesterolemia16 (22)3131 (6)
    Phosphorus14 (19)0148 (11)
    Hypokalemia10 (14)191 (1)
    Alanine aminotransferase increased10 (14)0100 (0)
    Hyponatremia7 (9)161 (1)
    Hyperkalemia4 (5)043 (4)
    Hypoglycemia4 (5)041 (1)
  • * Number of patients with at least one post-baseline value. Patients without any change from the baseline are excluded.

  • From <CTCAE Grade 3 to ≥CTCAE Grade 3 or from CTCAE Grade 0 to ≥CTCAE Grade 2.