Table 3.

Univariate and multivariate Cox proportional hazards regression analysis for associations with PSA-specific biochemical failure

PHazard ratio (95% CI)
Univariate analysis
    Collagen XXIII, continuous0.011.3 (1.1-1.5)
    Collagen XXIII, positive cutoff ≥1.20.0052.5 (1.3-4.8)
    Gleason score*
        70.072.5 (0.9-6.5)
        8-100.0033.8 (1.6-9.1)
    Preoperative PSA, ng/mL0.021.008 (1.001-1.01)
    Tumor stage
        T3 extraprostatic vs T2 organ-confined0.0023.6 (1.6-8.0)
    Positive surgical margins0.361.4 (0.7-2.9)
    Positive lymph nodes<0.0015.2 (2.7-9.9)
    Extraprostatic extension0.012.9 (1.3-6.5)
    Seminal vesicle invasion<0.0013.5 (2.0-6.4)
Multivariate analysis
    Collagen XXIII, positive cutoff ≥1.20.012.8 (1.2-6.5)
    Positive lymph nodes<0.0018.0 (3.2-19.9)
  • NOTE: Analysis was done on 76-patient group with minimum 5-y follow-up.

  • * Reference category is Gleason score 5 to 6.

  • Variables not included in the final multivariate model were nonsignificant (all P > 0.15).