Table 3.

Incidence and multiplicity of colonic neoplasia

GroupTreatmentNo.Incidence (no. mice with neoplasms)
Multiplicity (no. tumors/mice)*
no.miceTotalAdenomaAdenocarcinomaTotalAdenomaAdenocarcinoma
1AOM/DSS2013/20 (65%)12/20 (60%)9/20 (45%)3.7 ± 6.01.5 ± 1.82.2 ± 4.5
2AOM/DSS/0.016% UDCA208/20 (40%)6/20 (30%)5/20 (25%)0.9 ± 1.50.6 ± 1.10.3 ± 0.4
3AOM/DSS/0.08% UDCA209/20 (45%)5/20 (25%)5/20 (25%)0.6 ± 0.80.4 ± 0.70.3 ± 0.4
4AOM/DSS/0.4% UDCA208/20 (40%)8/20 (40%)4/20 (20%)1.0 ± 1.50.7 ± 0.90.3 ± 0.7
5AOM/DSS/0.05% SASP2011/20 (55%)9/20 (45%)8/20 (40%)1.6 ± 1.90.9 ± 1.10.7 ± 1.0
60.4% UDCA50/4 (0%)0/4 (0%)0/4 (0%)000
70.05% SASP50/5 (0%)0/5 (0%)0/5 (0%)000
8None50/5 (0%)0/5 (0%)0/5 (0%)000
  • * Values are expressed as mean ± SD.

  • P < 0.05, significantly different from group 1 by Tukey's multiple comparison post-test.