Table 5.

mRNA expression of COX-2, iNOS, PPARγ, and TNF-α in colonic mucosa at week 5

Group Treatment mRNA/GAPDH mRNA ratio (××104)
no.(no. mice examined)COX-2iNOSPPARγTNF-α
1AOM + 1% DSS (5)1.03 ± 0.46*1.41 ± 0.695.13 ± 1.007.98 ± 3.38
2AOM + 1% DSS/0.016% UDCA (5)1.25 ± 0.400.15 ± 0.224.83 ± 0.872.60 ± 0.79
3AOM + 1% DSS/0.08% UDCA (5)0.70 ± 0.360.26 ± 0.216.50 ± 2.292.57 ± 1.06
4AOM + 1% DSS/0.4% UDCA (5)1.06 ± 0.400.52 ± 0.40§4.55 ± 1.083.38 ± 2.18§
5AOM + 1% DSS/0.05% SASP (5)1.07 ± 0.891.19 ± 0.515.34 ± 0.755.00 ± 2.38
60.4% UDCA (5)0.04 ± 0.010.02 ± 0.012.51 ± 1.081.00 ± 0.48
70.05% SASP (5)0.08 ± 0.070.03 ± 0.022.49 ± 0.430.65 ± 0.32
8None (5)0.07 ± 0.060.06 ± 0.062.90 ± 0.830.79 ± 0.72
  • NOTE: Values are expressed as mean ± SD.

  • * P < 0.05, significantly different from group 8 by Bonferroni's multiple comparison post-test.

  • P < 0.01, significantly different from group 8 by Bonferroni's multiple comparison post-test.

  • P < 0.001, significantly different from group 1 by Bonferroni's multiple comparison post-test.

  • § P < 0.01, significantly different from group 1 by Bonferroni's multiple comparison post-test.