Table 5.

Relationship between IGH-involved translocation and clinicopathologic and immunohistochemical features

FactorsIGH-involved translocation
Positive (%) n = 36Negative (%) n = 76P
Mean age (y)54620.034*
Sex
    Male20 (56)48 (63)NS
    Female16 (44)28 (37)
Histology
    DLBCL + MALT14 (39)37 (49)NS
    DLBCL22 (61)39 (51)
Macroscopic type
    Mass forming20 (69)46 (72)NS
    Others9 (31)18 (28)
Depth of invasion
    Mucosa∼MP15 (45)32 (46)NS
    Serosa18 (55)38 (54)
Clinical stage
    I14 (41)43 (57)0.099
    II1 or more20 (59)33 (43)
H pylori status
    Positive22 (96)52 (95)NS
    Negative1 (4)3 (5)
Response to eradication
    CR1 (17)3 (14)NS
    Non-CR5 (83)19 (86)
Overall CR induction
    Yes35 (97)67 (88)0.107
    No1 (3)9 (12)
Progression or relapse
    Yes6 (17)20 (26)0.188
    No30 (83)56 (74)
BCL6 translocation
    Positive10 (33)6 (12)0.019
    Negative20 (67)46 (88)
c-MYC translocation
    Positive5 (21)2 (4)0.035
    Negative19 (79)47 (96)
FOXP1 translocation
    Positive3 (9)1 (2)0.134
    Negative30 (91)57 (98)
Extra copy of MALT1/BCL2
    Positive8 (25)17 (25)NS
    Negative24 (75)51 (75)
Extra copy of FOXP1/BCL6
    Positive8 (24)13 (22)NS
    Negative26 (76)47 (78)
Extra copy of c-MYC
    Positive2 (8)5 (10)NS
    Negative22 (92)43 (90)
CD10 expression
    Positive14 (54)33 (44)NS
    Negative22 (46)43 (56)
BCL6 expression
    Positive24 (67)41 (54)NS
    Negative12 (33)35 (46)
MUM1 expression
    Positive (n = 62)23 (64)38 (50)0.120
    Negative (n = 50)13 (36)38 (50)
Subgroup by Hans
    GCB17 (47)45 (59)NS
    Non-GCB19 (53)31 (41)
FOXP1
    Positive (n = 28)10 (40)18 (47)0.165
    Negative (n = 35)15 (60)20 (53)
  • * Mann-Whitney U test.

  • Fisher's exact probability test.