Table 3.

Multivariate survival analysis (forward LR method) of Axl and Gas6 protein expression in GBM patients

VariableTTP
OS
HR (95% CI)PP
Axl GIS (≤6 vs >6)3.2 (1.5-6.8)0.0010.09
    Age (≥60 vs <60)NSNS
    KPS (≥80 vs <80)NSNS
    Tumor location (frontal vs nonfrontal)NSNS
    Extend of resection (total/subtotal vs partial)NSNS
    Chemotherapy (+ vs −)NSNS
    Radiation (+ vs −)NSNS
Axl/Gas6 GIS (≤6 vs >6)3.6 (1.5-8.4)0.0030.142
    Age (≥60 vs <60)NSNS
    KPS (≥80 vs <80)NSNS
    Location (frontal vs nonfrontal)NSNS
    Resection (total/subtotal vs partial)NSNS
    Chemotherapy (+ vs −)NSNS
    Radiation (+ vs −)NSNS
  • NOTE: Gas6 expression alone was not significant (TTP: P = 0.392; OS: P = 0.144).

    Abbreviations: NS, not significant; HR, hazard ratio; 95% CI, 95% confidence interval.