Table 1.

Adverse events experienced by more than two patients

Most frequently reported nonhematologic toxicities (at least two patients) regardless of causality (all cycles, worst toxicity grade by patient)
Adverse eventNo. patients with grade 1-2/3* adverse events
All cohorts
Group A (daily × 5)
Group B (weekly)
Dose level (μg/kg)
100
500
1,000
100
1,000
2,000
n = 3n = 3n = 3n = 4n = 3n = 3N = 19
Chills2/03/03/03/02/03/016/0
Fever2/03/01/13/02/12/013/2
Headache1/13/03/02/01/010/1
Fatigue1/02/02/02/01/02/010/0
Pain (back/extremity)3/05/01/01/010/0
Pruritus/pruritic rash1/03/02/02/01/09/0
Nausea2/02/02/01/01/08/0
Pain1/02/02/02/01/08/0
Myalgia/arthralgia2/01/01/01/03/08/0
Anorexia1/02/01/02/01/07/0
Vomiting1/01/02/01/01/06/0
Diarrhea1/01/02/01/01/06/0
Cough1/01/02/01/01/06/0
Dizziness1/02/01/01/01/06/0
Insomnia2/02/01/05/0
Injection site/skin reaction1/03/01/05/0
Abdominal pain/distension3/01/01/05/0
Chest pain1/01/01/02/05/0
Rash/urticaria1/02/01/01/05/0
Paresthesia/hypoesthesia1/01/01/01/04/0
Hypotension1/01/00/11/03/1
Hypertension2/02/0
  • * No grade 4 adverse events were reported.