Table 2.

Common laboratory abnormalities seen during rhIL-18 administration

Common laboratory abnormalities (all cycles, worst toxicity grade by patient)
Laboratory abnormalityNo. patients with grade 1-2/3-4* adverse events
All cohorts
Group A (daily × 5)
Group B (weekly)
Dose level (μg/kg)
100
500
1,000
100
1,000
2,000
n = 3n = 3n = 3n = 4n = 3n = 3N = 19
Lymphopenia1/20/22/10/40/30/23/14
Anemia2/02/03/03/13/01/014/1
Leukopenia2/01/02/03/02/01/011/0
Neutropenia1/01/02/01/01/16/1
Hyperglycemia1/02/12/12/12/01/010/3
Hypoalbuminemia2/02/02/02/03/011/0
Elevated alkaline phosphatase2/01/01/11/02/02/09/1
Elevated AST2/02/02/02/08/0
Elevated creatinine1/01/03/02/01/08/0
Hyponatremia1/01/01/01/01/05/0
Elevated ALT1/01/02/04/0
Elevated bilirubin1/01/01/01/04/0
  • Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.

  • * All grade 3 with the exception of single episode of grade 4 hyperglycemia.

  • Grade 4 hyperglycemia.