Table 2.

Increased antitumor activity of vaccine plus docetaxel

TreatmentnTumor volume (day 37; mm3)P = (vs:)
NoneDocetaxelVaccineVaccine + docetaxel
None132038 ± 2320.760.120.003
Docetaxel142199 ± 4090.760.1970.030
Vaccine131575 ± 1070.120.1970.036
Vaccine + docetaxel151206 ± 850.0030.0300.036
  • NOTE: CEA-Tg mice were implanted s.c. with MC38-CEA+ tumors on day 0. Mice were either not treated (none), treated with docetaxel alone, vaccine alone, or first vaccinated and then treated with docetaxel (Fig. 5). Shown is average group tumor volumes at day 37. Bold numbers indicate statistical significance (P < 0.05).