Table 1.

Quantitative assessment of histopathologic alterations of kidneys 7 months after treatment with different activities of 225Ac-DOTATOC

Received activity of Actinium-225-DOTATOC (kBq)TubulesGlomeruliInterstitium
125+++++++
125+++++++
130+++++++
125+++++++
125+++++
60++++++
60+++++
65+++++
60++++++
65+++++
30+++++
35++++
30++++/−+++
30+++/−++
30+++++++
20Infiltrates
20Infiltrates
20Infiltrates
20Infiltrates
20Infiltrates
10Infiltrates
5Infiltrates
10Infiltrates
10Infiltrates
  • NOTE: The histopathologic changes in the renal tubuli, the glomeruli, and the renal interstitium in mice treated with the indicated amounts of 225Ac-DOTATOC were quantified by a semiquantitative score.