Table 3.

Multivariate analyses of factors associated with OS and DFS (CK10 and CK19, respectively)

MedianSurvivalHazard ratio (95% CI)P
OS*
    Liver cirrhosis (no vs yes)NA691.92 (1.10-3.38)0.023
Tumor encapsulation (complete vs none)99521.51 (1.09-2.08)0.013
    Tumor size, cm (≤5 vs >5)96511.45 (1.05-2.00)0.026
    TNM stage (I vs II-III)97422.10 (1.45-3.04)<0.0001
    CK10 (negative vs positive)88501.71 (1.17-2.52)0.0059
    CK19 (negative vs positive)88462.02 (1.41-2.90)0.00014
DFS
    TNM stage (I vs II-III)NA382.24 (1.49-3.37)0.0001
    CK10 (negative vs positive)NA202.79 (1.87-4.17)<0.0001
  • NOTE: Multivariate analysis and Cox proportional hazards regression model were used. Variables were adopted for their prognostic significance by univariate analysis with forward stepwise selection (forward, likelihood ratio). Variables were adopted for their prognostic significance by univariate analysis (P < 0.05).

    Abbreviation: NA, not applicable.

  • * CK10, CK19, liver cirrhosis, tumor differentiation, tumor encapsulation, tumor size, TNM stage, vascular invasion, and tumor number were included in multivariate analysis for OS.

  • CK10, tumor encapsulation, vascular invasion, tumor size, and TNM stage were included in multivariate analysis for DFS.