Table 1.

Sensitivity patterns identified by COMPARE

CompoundNSCMechanism of actionCorrelation (PCC), GI50
A. Melphalan
    Chlorambucil3088DNA alkylator, nitrogen mustard0.934
    Thio-TEPA6396DNA alkylator0.909
    Piperazine, 1-(2-chloroethyl)-4-(3-chloropropyl)-, dihydrochloride344007DNA alkylator, nitrogen mustard0.913
    2-Hexanamine, 1,6-dichloro-N-(2-chloroethyl)-, hydrochloride9713DNA alkylator, nitrogen mustard0.902
    YOSHI 864102627DNA alkylator0.876
    Hepsulfam329680DNA alkylator0.875
B. Chlorambucil
    Uracil mustard34462DNA alkylator, nitrogen mustard0.957
    Aziridine, 1,1′-[tetramethyl-p-phenylenebis(methylenecarbonyl)]bis-48034DNA alkylator0.916
    Melphalan8806DNA alkylator, nitrogen mustard0.896
    Epoxypiperazine74437DNA alkylator0.895
    2-Hexanamine, 1,6-dichloro-N-(2-chloroethyl)-, hydrochloride9713DNA alkylator, nitrogen mustard0.894
    Diiodobenzotepa167781DNA alkylator0.892
    Piperazine, 1-(2-chloroethyl)-4-(3-chloropropyl)-, dihydrochloride344007DNA alkylator, nitrogen mustard0.886
    Vercyte25154DNA alkylator0.880
    Thio-TEPA6396DNA alkylator0.875
C. Cyclophosphamide
    MX2 HCl619003Anthracycline, DNA intercalator0.934
    Fotrin216135DNA alkylator0.878
    1-Aziridinecarboxamide, N,N′-hexamethylenebis(2-methyl)54059DNA alkylator0.877
    Bis(2-chloroethyl)-N-methyl-N-(3-methyl-2-nitrobenzyl)ammonichloride658929DNA alkylator0.852
    Menogaril269148Anthracycline, DNA intercalator0.847
    Thio-TEPA6396DNA alkylator0.832
    YOSHI 864102627DNA alkylator0.812
    Melphalan8806DNA alkylator, Nitrogen mustard0.765
    Chlorambucil3088DNA alkylator, nitrogen mustard0.762
D. Bendamustine
    CTIC, dacarbazine45388DNA alkylator, methylating agent0.792 (LC50)
    TOPT1B376254Topoisomerase I inhibitor0.619 (TGI)
    N-N-Dibenzyl-daunomycin268242Anthracycline, DNA intercalator (daunomycin analogue)0.574 (TGI)
    Melphalan8806DNA alkylator, nitrogen mustard0.550 (GI50)
    YOSHI 864102627DNA alkylator0.542 (GI50)
    Ara-AC (Fazarabine)281272Antimetabolite and DNA methylation inhibitor0.524 (TGI)
  • NOTE: Twenty-five compounds showed a PCC of >0.839 for melphalan; 25 compounds showed a PCC of >0.839 for chlorambucil; 23 compounds showed a PCC of >0.8 for cyclophosphamide; and no compound showed a PCC of >0.8 for bendamustine.