Table 2.

Gene Ontology consortium statistical analysis of bendamustine-induced gene changes in SU-DHL-1 cells

Functional groupsGO no.GO description: biological processBENDAPMCHLB
DNA-damage, stress response, apoptosis6974Response to DNA damage stress0.000010.0041NA
6950Response to stress0.0003NANA
16265Death0.0482NA0.0428
DNA metabolism, DNA repair, transcription6259DNA metabolism0.000030.0433NA
6139Nucleobase, nucleoside, nucleotide, and nucleic acid metabolism0.0004NANA
6357Regulation of transcription from Pol II promoter0.0003NA0.0109
6366Transcription from Pol II promoter0.0068NA0.0269
Cell proliferation, cell cycle, mitotic checkpoint8283Cell proliferation0.000010.0030.0232
8151Cell growth and/or maintenance0.00410.0464NA
6275Regulation of DNA replication0.01010.0101NA
278Mitotic cell cycle0.03340.0084NA
79Regulation of CDK activity0.0192NANA
7078Mitotic metaphase plate congression0.047NANA
50790Regulation of enzyme activity0.0363NANA
Cell regulation50789Regulation of biological process0.000040.000060.0016
50794Regulation of cellular process0.00350.00070.0012
9987Cellular process0.0379NANA
  • NOTE: The last three columns are the probability that each immediate daughter term (a P value) is linked to the number of selected genes by chance; P value was calculated using the GO3 software.

    Abbreviations: BENDA, bendamustine; CHLB, chlorambucil; NA, no P value given: no linkage observed; PM, phosphoramide mustard (cyclophosphamide metabolite).