Table 2.

Adverse events in nilotinib patients at 400 mg twice daily

Grade 1 or 2 (%)Grade 3 or 4 (%)
Nonhematologic events
    Rash, all types (%)220
    Pruritus63
    Dry skin60
    Constipation00
    Nausea, vomiting, or both130
    Increase in both total and conjugated bilirubin levels63
    Fatigue160
    Increase in unconjugated bilirubin level63
    Alopecia00
    Increase in lipase level09
    Increase in level of ALT, AST, or both33
Hematologic events
    Thrombocytopenia325
    Neutropenia09
    Anemia06
  • Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.