Table 1.

Frequency of the EML4-ALK fusion gene in NSCLC tumors and its association with clinical, pathologic, and genetic factors

Clinical, pathologic, and genetic characteristicsEML4-ALK, n (%)
P*
+
All tumors8 (3)297 (97)
Ethnicity
    U.S. cohort2 (1)136 (99)NS
    Korean cohort6 (3)167 (97)
Gender
    Male3 (2)184 (98)NS
    Female5 (4)119 (96)
Smoking (<10 pack-years)
    Never4 (6)65 (27)0.049
    Smoker2 (1)182 (73)
Age, median (y)55.961.9
Stage
    I4 (2)179 (98)NS
    II1 (2)58 (98)
    III3 (6)47 (94)
    IV0 (0)9 (100)
Histology
    Adenocarcinoma8 (4)200 (96)NS
    Squamous cell carcinoma0 (0)88 (100)
    Adenosquamous carcinoma0 (0)9 (100)
Oncogenic mutations
    EGFR1 (1)68 (99)NS
    KRAS0 (0)49 (100)
    BRAF0 (0)4 (100)
  • * Fisher's exact test. NS, not statistically significant (P > 0.05).