Table 2.

Fus1 immunohistochemical expression in lung cancer and epithelial foci using tissue microarray specimens

Histology of samplesNo. of samplesFus1 score, mean (SD)Fus1 score levels
Lost (negative) n (%)Reduced (low + intermediate) n (%)Preserved (high) n (%)P value, Fus1 levels
Cancer specimensComparison between tumors
    SCLC2257 (67.4)9 (41)13 (59)00.0008
    NSCLC281121 (87.3)36 (13)194 (69)51 (18)
        Adenocarcinoma172127 (91.8)25 (15)110 (64)37 (22)0.07
        Squamous cell carcinoma109111 (79.1)11 (10)84 (77)14 (13)
Epithelial specimensComparison between normal and abnormal epithelia*
Score
Level
    Normal epithelium68251 (46.6)027 (40)41 (60)RefRef
    Basal cell hyperplasia120263 (47.5)040 (33)80 (67)0.350.68
    Squamous metaplasia23215 (46.0)018 (78)5 (22)0.0140.014
    Squamous dysplasia62224 (51.3)025 (45)31 (55)0.00040.047
        Low-grade dysplasia14200 (39)012 (86)2 (14)0.0100.28
        High-grade dysplasia48231 (53)023 (48)25 (52)0.0050.019
    AAH56250 (52.3)025 (45)31 (55)0.610.79
  • * Mixed effect model was used to assess difference of scores between normal and abnormal epithelia. A GEE model was used to compare the differences in FUS1 level between normal and abnormal epithelia.

  • Normal epithelium was used as reference value (Ref).